Understanding

Charcot-Marie-Tooth Disease

Charcot-Marie-Tooth (shar-ko¯’ mä-re´ tooth) or CMT is a group of disorders that affects the peripheral nerves and consequently the muscles they innervate. CMT is one of the most common inheritable neuromuscular diseases, affecting an estimated one in 2,500 people worldwide. First discovered in 1886 by Jean-Marie Charcot, Pierri Marie and Howard Henry Tooth, today CMT affects more than 3 million people worldwide.

Although CMT is typically inherited from one’s parents, it can also develop as a result of a new or spontaneous mutation. Symptoms are variable and wide ranging and include pain, numbness, decreased sensation, muscle weakness and eventually muscle deterioration. Loss of normal function and sensation is often seen in the legs, feet, arms and hands. Most frequently the onset of symptoms occurs in the first 10 years of life, although symptoms may begin as early as birth or late into adulthood. CMT is a progressive condition with symptoms worsening over time and can be severely disabling. Currently there is no cure for CMT.

 
 

Resources

Supporting Organizations

A diagnosis of CMT affects every facet of a patient’s life and while there are no treatments, supportive care is critical to helping the patient lead fuller lives. Connecting with advocacy groups can inform patients about experts in the field, support groups and ongoing research.  Some organizations supporting CMT are listed below. Inclusion on this list is not an endorsement by Nurturing Neurons Guild.

 
 
 
 
 

PO Box 105
Glenolden, PA 19036
Toll-free: 1-800-606-2682
Telephone: +1-610-499-9264
Fax: +1-610-499-9267
E-mail: info@cmtusa.org
Website: https://www.cmtausa.org/

 
 
 

Building 22
Concord Hospital
Concord, NSW, 2139 Australia
Telephone: (02) 9767 5105
E-mail: cmtaa2@cmt.org.au
Website: https://www.cmt.org.au

 
 
 
 
 

3 Groveley Road
Christchurch, Dorset BH23 3HB
United Kingdom
Telephone: 0300 323 6316
E-mail: enquiries@cmt.org.uk
Website: https://www.cmt.org.uk/

 
 
 

4062 Peachtree Road
Suite A209
Atlanta, GA 30319
Telephone: (404) 806-7180
E-mail: info@cmtrf.org
Website: https://cmtrf.org/

 
 

401 Park Avenue, 10th Floor
New York, NY 10016
Toll-free: 1-855-435-7268
Telephone: +1-212-722-8396
Fax: +1-917-591-2758
E-mail: info@hnf-cure.org
Website: https://www.hnf-cure.org/

 
 
 

222 S Riverside Plaza
Suite 1500
Chicago, IL 60606
Toll-free: 1-833-275-6321 (Helpline)
E-mail: resourcecenter@mdausa.org
Website: https://www.mda.org

 
 

61A Great Suffolk Street
London, SE1 0BU United Kingdom
Toll-free: 0800 652 6352 (Helpline)
Telephone: (+44) 0 020 7803 4800
E-mail: info@musculardystrophyuk.org
Website: https://www.musculardystrophyuk.org/